Thank you to Taymount for our first Taymount Tuesday! The Taymount staff from the clinic answered questions pertaining to fecal transplant and to their own protocols and clinical experiences.
Below I will list the questions that were answered by video and give you the time stamp for finding those questions on the video if you wish to skim straight to your questions of interest. Below that are written questions that were answered by Taymount during the live Q & A portion of our Taymount Tuesday session on Facebook.
We hope that by bringing these to you on a regular basis, we’ll be able to answer many of the questions of our members.
Questions answered on the video:
Question 1 Location on video 0.26 minutes
After a treatment with antibiotics for sinus infection, I have had diarrhea as many as 30+ times in a 24 hour period. I was hospitalized for 12 days. I still have diarrhea 4-6 times daily for over 3 months even with heavy daily anti-diarrhea meds. Because I don’t have C-Diff etc, Can my condition Ever warrant FMT? I’m desperate…
Question 2 Location on video 2.25 minutes
I recently spoke with a doctor in my area who does FMT. He said that while it does save folks with c.diff infections in the short run, that several that he had tracked for years after the procedure had gone on to develope a variety of autoimmune diseases (not just aggrevating a Crohn’s flare in the short run)…So I’d like your clinic to compare long term outcomes if possible and speak about long term safety in general.
Question 3 Location on video 3.37 minutes
I’ve been chronically ill for over 7 years now following taking a lot of antibiotics over a short period for multiple medical issues. My long term symptoms include chronic diarrhoea, chronic fat malabsorption (gall bladder removed-diseased, no stones), fatigue, malnutrition, histamine triggers etc. I’ve become convinced that my illness is the result of damage that antibiotics caused to my microbiome. At this point I am particularly interested in FMT and how that may be a treatment consideration. The majority of the research that I’ve found however refers to c.diff treatment. Are you aware of studies relevant to my condition and if so can you recommend where to look?
Question 4 Location on video 5.20 minutes
I have ulcerative colitis, hypothyroidism from Hashimoto’s and Uveitis (and persistent systemic inflammation). From the results of numerous stool microbiology tests, it seems I do not have any physiological escherichia Coli in my gut (which gets reported as being “abnormal”). The lab that does the test recommended I take e. Coli probiotics (which they supply), but about 2 weeks after I started taking them I had a UC flare-up, which seemed to get better slowly after stopping this strain of probiotics. A fecal test since then again shows 0 (abnormal) e. Coli – even after the heavy dosages of e.Coli I was taking (during this same period, all other commensal flora have seen a fantastic increase – now to “normal” levels due to my heightened focus on probiotic and prebiotic supplementation and diet). From my own research, there is some thinking that commensal bacteria (like physiological e. Coli) can cause autoimmine responses in susceptible individuals. And I suspect my body sees commensal e. Coli as an invader and launches its attack when it sees it – hence my flare up and the fact that the e. Coli supplementation did not result in any colonization in my colon. Could this be the case? And if so, would FMT be worthwhile for me – or would it potentially make my autoimmune conditions worse due to the donor’s microbiota (which would likely contain e. Coli and potentially other organisms that my immune system may react to) causing my immune system to attack the new “invaders”? Have you had experiences like this in the past? And are you able to “manipulate”/choose donors or the FM to avoid certain organisms for certain people?
Question 5 Location on video 7.55 minutes
Besides FMT as an attempt to positively influence the health status of an individual, there are many people who use helminths with the same intention. Just like bacteria, helminths have been shown to influence the microbiome, modulate the immune system and thereby they can have positive or negative influences on the immune system depending on the species and the individual.
So my question is: Does the Taymount clinic consider to watch for donors that are different from the donors that are recruited now,? For example: Healthy people who host parasites that are non pathogenic? I personally would be very interested in FMTs that come from a donor who fulfills the criteria that Taymount donors have to fulfill, but who is colonized by Trichuris Trichiura in addition to that.
Question 6 Location on video 8.48 minutes
I was told by the clinic that FMTs from the clinic can be used for 6 months if frozen at -18°C. My question is:
Did you conduct any experiments regarding how the quality of an FMT changes under frozen conditions. I mean, could one also use an FMT that has been frozen for more than 6 months under -18°C and if so, how long can it actually be effective?
Question 7 Location on video 11.36 minutes
I have a question regarding FMT and my condition: primary sclerosing cholangitis, an autoimmune disease in the bile ducts. My questions:
– do you have any success stories of using FMT for PSC? How does maintenance look like from your experience?
– I have found success stories of using rifaximin and vancomycin months leading to the FMT treatments to reduce pathogenic overgrowth, do you have any opinion on this approach?
Question 8 Location on video 14.27 minutes
1 – If I was to perform a DIY FMT enema at home, would a medical foleys catheter (urinary catheter) be beneficial in terms of reach and just how far into my colon would it go?
2 – With regards to DIY FMTs done to correct dysbiosis, what would be the recommended number of FMT enema repeats if one has not taken an antibiotic course prior?
Question 9 Location on video 15.31 minutes
Has there been any research or will there be any research in regards to FMT and mitochondrial issues or genetic mutations?
Question 10 Location on video 16.49 minutes
Would it be beneficial for reference if patients were to track the before and after of their gut’s bacteria using a stool testing lab?
Question 11 Location on video 18.38 minutes
My daughter had an FMT when she was 13 in a clinical study. She got really sick from it and the researcher thought that it was because at the time she was having a mini flare. 3 years later she’s been in remission, thanks to remicade and methotrexate. My question is, now that’s she’s symptom free, would it be advisable for her to try the FMT again? My objective is to stop those horrible medications that cause her other problems. She is now 16 and has Crohns. Thank you!
Question 12 Location on video 23.19 minutes
Taymount has been conducting FMT treatment for a number of years now. Have they, or will they compile statistical data on conditions they treat and will they make this available to patients so they can be informed about statistical odds of success when considering FMT treatment? The markers for “success” being clearly defined so patients can make an informed decision.
What does the future hold in regards to FMT treatment and how will it align with the evolving field of microbiome research?
Written Questions & Answers During Our Facebook Q & A
It looks like we’re experiencing some technical difficulties with the Taymount replies on Facebook. I’ll post these when we have things worked out.